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    ZNF570 zinc finger protein 570 [ Homo sapiens (human) ]

    Gene ID: 148268, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF570provided by HGNC
    Official Full Name
    zinc finger protein 570provided by HGNC
    Primary source
    HGNC:HGNC:26416
    See related
    Ensembl:ENSG00000171827 AllianceGenome:HGNC:26416
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 2.3), thyroid (RPKM 1.8) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    19q13.12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (37467772..37488652)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (40269271..40290151)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37958674..37979554)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14541 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:37809147-37810044 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:37811117-37811765 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:37811766-37812414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37824558-37825500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37825501-37826442 Neighboring gene zinc finger protein 875 Neighboring gene MPRA-validated peak3463 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10555 Neighboring gene zinc finger protein 527 Neighboring gene zinc finger protein 569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14548 Neighboring gene ZNF793 antisense RNA 1 (head to head) Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37996759-37997550 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37997551-37998342 Neighboring gene zinc finger protein 793 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:38020876-38021698 Neighboring gene uncharacterized LOC124904708 Neighboring gene ZNF571 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The in vivo Interaction Landscape of Histones H3.1 and H3.3. Siddaway R, et al. Mol Cell Proteomics, 2022 Oct. PMID 36089195, Free PMC Article
    2. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article
    3. A proximity-dependent biotinylation map of a human cell. Go CD, et al. Nature, 2021 Jul. PMID 34079125
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ30791

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 570

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300993.3 → NP_001287922.1  zinc finger protein 570 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC008806, AK308252, BM671447, BQ773525
      Consensus CDS
      CCDS74355.1
      UniProtKB/TrEMBL
      K7EP39
      Related
      ENSP00000467218.1, ENST00000586475.5
      Conserved Domains (4) summary
      smart00349
      Location:70 → 130
      KRAB; krueppel associated box
      COG5048
      Location:307 → 572
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:388 → 408
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:288 → 313
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001321991.3 → NP_001308920.1  zinc finger protein 570 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008806, AK055353, BM671447, BP312352
      Consensus CDS
      CCDS12504.1
      UniProtKB/Swiss-Prot
      A1L472, B4DMP1, Q96NI8
      Conserved Domains (4) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:251 → 516
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:332 → 352
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:232 → 257
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001321992.3 → NP_001308921.1  zinc finger protein 570 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC008806, BC130425, BM671447
      UniProtKB/Swiss-Prot
      Q96NI8
      Conserved Domains (4) summary
      COG5048
      Location:209 → 474
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:290 → 310
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:190 → 215
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:1 → 32
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    4. NM_001321993.3 → NP_001308922.1  zinc finger protein 570 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC008806, AK297561, BC130425, BM671447
      UniProtKB/Swiss-Prot
      Q96NI8
      Conserved Domains (3) summary
      COG5048
      Location:48 → 313
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:129 → 149
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:29 → 54
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001321994.3 → NP_001308923.1  zinc finger protein 570 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC008806, AK297561, BC130425, BM671447
      UniProtKB/Swiss-Prot
      Q96NI8
      Conserved Domains (3) summary
      COG5048
      Location:48 → 313
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:129 → 149
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:29 → 54
      zf-H2C2_2; Zinc-finger double domain

    6. NM_144694.5 → NP_653295.1  zinc finger protein 570 isoform 2

      See identical proteins and their annotated locations for NP_653295.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC008806, BC130425, BM671447
      Consensus CDS
      CCDS12504.1
      UniProtKB/Swiss-Prot
      A1L472, B4DMP1, Q96NI8
      Related
      ENSP00000331540.1, ENST00000330173.6
      Conserved Domains (4) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:251 → 516
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:332 → 352
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:232 → 257
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      37467772..37488652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      40269271..40290151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96NI8.1 GenPept UniProtKB/Swiss-Prot:Q96NI8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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